All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit the International Myeloma Foundation or HealthTree for Multiple Myeloma.
Introducing
Now you can personalise
your Multiple Myeloma Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe Multiple Myeloma Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the Multiple Myeloma Hub cannot guarantee the accuracy of translated content. The Multiple Myeloma Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
Autologous stem cell transplantation (ASCT) is the standard of care for younger (< 65-70) and/or fitter multiple myeloma (MM) patients (pts). Briefly, following an induction therapy, stem cells (SCs) are collected from the patient’s peripheral blood (PB) and are usually stored in liquid nitrogen (-196oC) in a solution that contains the cryoprotectant dimethyl sulfoxide (DMSO). After receiving high-dose chemotherapy with melphalan, pts undergo ASCT using the stored PBSCs.
Storing the SCs in liquid nitrogen requires expensive equipment and well-trained personnel. In addition, the use of DMSO can cause some mild or severe adverse reactions in some pts. Maria Cecilia Borges Bittencourt, from the Department of Hematology, University of Sao Paulo, Sao Paulo, Brazil, and collaborators, examined the efficacy and safety of ASCT using PBSC that were either cryopreserved in liquid nitrogen (CRYO) or kept in liquid state for up to 48 hours at 4oC (non-CRYO) in blood bank refrigerators. The primary endpoint of the trial was neutrophil engraftment (NE). Secondary endpoints included early transplantation related mortality (TRM), infection, infusion-related complications, and costs. The results of the study were published in the journal Bone Marrow Transplantation in August 2018.
Data is given as CRYO vs non-CRYO
This study reveals that non-CRYO ASCT is non-inferior to CRYO ASCT and can be used effectively in multiple myeloma. NE was achieved earlier in the non-CRYO group compared to the CRYO group, and the number of infections was similar between the two groups. Non-CRYO offers the advantage of being more cost-effective, which provides a great benefit for countries with limited cryopreservation resources and budget. Moreover, in the non-CRYO procedure pts do not develop AEs related to the presence of DMSO. A drawback of the non-CRYO method is that SCs are not available for a second ASCT. The findings of this study are in accordance with the fact that SCs remain viable for up to 3-5 days when stored in liquid state in blood bank refrigerators at 1-6o C.
Your opinion matters
Subscribe to get the best content related to multiple myeloma delivered to your inbox